The Barretos Cancer Hospital Animal Facility: implementation and results of a dedicated platform for preclinical oncology models

• Author(s): Teixeira, Silvia A. ; Luzzi, Mayara de Cassia ; Martin, Ana Carolina Baptista Moreno ; Duarte, Terence Teixeira ; Leal, Mônica de Oliveira ; Teixeira, Gustavo Ramos ; Reis, Monise Tadin ; Junior, Carlos Roberto Almeida ; Santos, Karina ; Melendez, Matias Eliseo ; Silva, Diego da Cunha Silveira Alves da ; Bernécule, Priscila Neves ; Firmino, Higor Vinicius Lourenço ; Alves, Ana Laura Vieira ; Guimarães, Denise Peixoto ; Borduqui, João Vitor ; Laus, Ana Carolina ; Mançano, Bruna Minniti ; Reis, R. M.
• Date: 2022
• Persistent ID: https://hdl.handle.net/1822/81321
• Origin: RepositóriUM - Universidade do Minho
• Subject(s): PTCH1-knockout; Apc^Min; xenografts; PDX; genetically engineered mouse models; personalized therapy; tumor biology; Apc(Min)
• Document Type: Journal article
• Language: English
• Contributor(s): Universidade do Minho

Description

The Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and Apc^Min mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the progress and challenges in establishing these models and the need for having an appropriate representation of our cancer population to better understand tumor biology and to identify cancer biomarkers, which could be putatively targeted, allowing for personalized therapy.