Author(s): Pinto, Joana ; Gonçalves, M. Sameiro T. ; Pereira, David M.
Date: 2024
Persistent ID: https://hdl.handle.net/1822/94804
Origin: RepositóriUM - Universidade do Minho
Subject(s): benzo[a]phenoxazines; anti-inflammatory agents; COX-2; LOX enzymes
The chemical diversity of natural products provides a promising source of anti-inflammatory drugs, notably targeting COX-2, whose activity is associated with inflammatory processes and carcinogenesis. The COX-2 and LOX inhibitory capacity of several benzo[a]phenoxazines, N- and O-heterocyclic compounds, was studied. The kinetic assay results revealed that these molecules significantly inhibit COX-2 activity, highlighting their promise as potent anti-inflammatory agents.
