Author(s): Paula, Roberta S. ; Souza, Vinícius C. ; Machado-Silva, Wilcelly ; Almeida, Bruno Ratier S. ; Daros, Andersen C. ; Gomes, Lucy ; Ferreira, Aparecido P. ; Brito, Ciro J. ; Córdova, Cláudio ; Moraes, Clayton F. ; Nóbrega, Otávio T.
Date: 2016
Origin: Oasisbr
OBJECTIVES: The number of deaths from vascular diseases is incredibly high worldwide, and reliable markers for major events are still needed. The current cross-sectional study investigated the association of Klotho haplotypes and Klotho serum levels with classic risk factors and a clinical history of vascular events. METHODS: Clinical, anthropometric, biochemical and nutritional assessments were conducted with 168 older adults, complemented by genotyping (rs9536314 and rs9527025) and the detection of serum Klotho (ELISA). RESULTS: Klotho levels and haplotypes did not associate with most classic risk factors for vascular events, including markers such as C-reactive protein and homocysteine. A positive association was only found between Klotho levels and the previous occurrence of a myocardial infarction by both correlational (p=0.006) and variance analyses (p
