Author(s): Cáceres, Diego H. ; Zuluaga, Alejandra ; Tabares, Ángela M. ; Chiller, Tom ; González, Ángel ; Gómez, Beatriz L.
Date: 2017
Origin: Oasisbr
Subject(s): Cryptococcosis; Cryptococcus; Antigen; Diagnosis; Point-of-care; Lateral Flow Assay; Immunochromatographic assay; Latex agglutination system
A Lateral Flow Assay to detect cryptococcal antigen (CrAg® LFA) in serum and cerebrospinal fluid for the rapid diagnosis of cryptococcosis was evaluated. A retrospective validation was performed. Sensitivity and specificity of the CrAg® LFA was 100%. High concordance (kappa index=1.0) between Cryptococcal Antigen Latex Agglutination System (CALAS®) and CrAg® LFA was observed. CrAg® LFA showed higher analytical sensitivity for detecting low concentrations of cryptococcal antigen.
