Author(s): Souza, Yglesio Moyses de ; Fontes, Belchor ; Martins, Joilson O ; Sannomiya, Paulina ; Brito, Glacus S. ; Younes, Riad N. ; Rasslan, Samir
Date: 2010
Origin: Oasisbr
Subject(s): IL-6; IL-10; CINC-1; Sepsis; ALI; CLP
Document details
Evaluation of the effects of ozone therapy in the treatment of intra-abdominal infection in rats
Description
INTRODUCTION: The antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial. OBJECTIVES: To evaluate the effect of intraperitoneal (i.p.) O3 application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced neutrophil chemoattractant (CINC)-1 serum levels, acute lung injury and survival rates. METHODS: Four animal groups were used for the study: a) the SHAM group underwent laparotomy; b) the cecal ligation/puncture group underwent cecal ligation/puncture procedures; and c) the CLP+O2 and CLP+O3 groups underwent CLP+ corresponding gas mixture infusions (i.p.) throughout the observation period. IL-6, CINC-1 and IL-10 concentrations were determined by enzyme-linked immunosorbent assay (ELISA). Acute lung injury was evaluated with the Evans blue dye lung leakage method and by lung histology. P
Document Type
Journal article
Language English
Language English
