Author(s): Sadeghi, Masoumeh ; Roohafza, Hamidreza ; Afshar, Hamid ; Rajabi, Fereshteh ; Ramzani, Mohamadarash ; Shemirani, Hasan ; Sarafzadeghan, Nizal
Date: 2011
Origin: Oasisbr
Subject(s): Coronary risk factors; Coronary heart disease; Major depression
OBJECTIVE: To investigate the relation between major depressive disorder and metabolic risk factors of coronary heart disease. INTRODUCTION: Little evidence is available indicating a relationship between major depressive disorder and metabolic risk factors of coronary heart disease such as lipoprotein and apolipoprotein. METHODS: This case-control study included 153 patients with major depressive disorder who fulfilled the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV), and 147 healthy individuals. All participants completed a demographic questionnaire and Hamilton rating scale for depression. Anthropometric characteristics were recorded. Blood samples were taken and total cholesterol, high-and low-density lipoproteins and apolipoproteins A and B were measured. To analyze the data, t-test, χ2 test, Pearson correlation test and linear regression were applied. RESULTS: Depression was a negative predictor of apolipoprotein A (β = -0.328, p
