Amygdalar nuclei and hippocampal subfields on MRI: test-retest reliability of automated volumetry across different MRI sites and vendors

• Author(s): Quattrini, Giulia ; Pievani, Michela ; Jovicich, Jorge ; Aiello, Marco ; Bargalló, Núria ; Barkhof, Frederik ; Bartres-Faz, David ; Beltramello, Alberto ; Pizzini, Francesca B. ; Blin, Olivier ; Bordet, Regis ; Caulo, Massimo ; Constantinides, Manos ; Didic, Mira ; Drevelegas, Antonios ; Ferretti, Antonio ; Fiedler, Ute ; Floridi, Piero ; Gros-Dagnac, Hélène ; Hensch, Tilman ; Hoffmann, Karl-Titus ; Kuijer, Joost P. ; Lopes, Renaud ; Marra, Camillo ; Müller, Bernhard W. ; Nobili, Flavio ; Parnetti, Lucilla ; Payoux, Pierre ; Picco, Agnese ; Ranjeva, Jean-Philippe ; Roccatagliata, Luca ; Rossini, Paolo M. ; Salvatore, Marco ; Schonknecht, Peter ; Schott, Björn H. ; Sein, Julien ; Soricelli, Andrea ; Tarducci, Roberto ; Tsolaki, Magda ; Visser, Pieter J. ; Wiltfang, Jens ; Richardson, Jill C. ; Frisoni, Giovanni B. ; Marizzoni, Moira
• Date: 2020
• Persistent ID: http://hdl.handle.net/10773/36743
• Origin: RIA - Repositório Institucional da Universidade de Aveiro
• Subject(s): Amygdalar nuclei; Hippocampal subfields; Multicenter MRI study; FreeSurfer; Reliability analysis
• Document Type: Journal article
• Language: English

Description

The amygdala and the hippocampus are two limbic structures that play a critical role in cognition and behavior, however their manual segmentation and that of their smaller nuclei/subfields in multicenter datasets is time consuming and difficult due to the low contrast of standard MRI. Here, we assessed the reliability of the automated segmentation of amygdalar nuclei and hippocampal subfields across sites and vendors using FreeSurfer in two independent cohorts of older and younger healthy adults.