Author(s): Neves, AR ; Monteiro, P ; Matos, A ; Santos-Silva, I
Date: 2015
Persistent ID: http://hdl.handle.net/10400.4/1786
Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
Subject(s): Miastenia Gravis; Complicações na Gravidez; Recém-Nascido; Anticorpos; Receptores Proteína Tirosina Quinases
Myasthenia gravis is an autoimmune disorder affecting predominantly women in their reproductive age. The course of the disease during pregnancy is unpredictable, although it is more difficult to manage earlier in the gestation. Myasthenia gravis with antibodies against the muscle-specific receptor tyrosine kinase (anti-MuSK) has been described as a subtype of disease with more localised clinical features and a poorer response to treatment than acetylcholine receptor antibody (anti-AChR)-positive patients. Few cases have been reported in pregnant women, with deliveries being performed mainly by caesarean section. We report a successful case of vaginal delivery and describe our experience providing the first review of the management of this subtype of disease during pregnancy.
