Author(s): Moura, AL ; Pereira, C ; Regateiro, FS ; Azevedo, J ; Todo Bom, A ; Carrapatoso, I
Date: 2019
Persistent ID: http://hdl.handle.net/10400.4/2354
Origin: Repositório do Centro Hospitalar e Universitário de Coimbra
Subject(s): Hipersensibilidade Alimentar; Imunoterapia Sublingual
Introduction. Sublingual immunotherapy (SLIT) with Pru p 3 can prevent severe allergic reactions to LTP-containing foods, but the standard initiation protocol is time-consuming. Objectives. Establish the safety of a novel ultra-rush initiation protocol for SLIT with Pru p 3. Methods. Prospective study comparing the side effects of the standard vs novel ultra-rush initiation protocols of SLIT with Pru p 3 in patients with anaphylaxis to LTP. Results. Fifteen patients were included (standard initiation, 5; ultra-rush initiation, 10), 80% females. All patients had oropharyngeal pruritus during initiation, 80% with spontaneous recovery, but no other gastro-intestinal, respiratory, cutaneous or systemic side effects occurred in any patient of both groups. Conclusion. The novel ultra-rush protocol halved the build-up time without increasing side effects.
