Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formation and Gait Selection

• Author(s): Skarlatou, Sophie ; Hérent, Coralie ; Toscano, Elisa ; S. Mendes, César ; Bouvier, Julien ; Zampieri, Niccolò
• Date: 2020
• Persistent ID: http://hdl.handle.net/10362/100939
• Origin: Repositório Institucional da UNL
• Subject(s): Afadin; central canal development; gait; locomotor circuits; premotor connectivity; spinal cord; spinal interneurons; Biochemistry, Genetics and Molecular Biology(all)
• Document Type: Journal article
• Language: English
• Contributor(s): Centro de Estudos de Doenças Crónicas (CEDOC); NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM); RUN

Description

Skarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.