Author(s): Gouveia, Catarina ; Branco, Joana ; Norte, Susana ; Arcangelo, Joana ; Alves, Pedro ; Pinto, Margarida ; Tavares, Delfin
Date: 2022
Persistent ID: http://hdl.handle.net/10362/134680
Origin: Repositório Institucional da UNL
Subject(s): K. kingae; Myositis; Osteomyelitis; Paediatric; S. aureus; Pediatrics, Perinatology, and Child Health
ok
Introduction: Despite the current trend towards less aggressive therapeutic approaches, acute haematogenous osteomyelitis (AHO) continues to be a challenge and is associated with significant morbidity worldwide. Our aim was to determine if 80% compliance with current protocol was achieved, identify complications and associated risk factors and analyse trends in aetiology and management of AHO in children. Methods: We conducted a longitudinal, observational, single-centre study in patients with AHO aged less than 18 years admitted to a paediatric hospital, between 2008 and 2018, divided into 2 cohorts (before and after 2014). Demographic, clinical data and disease progression were analysed. Results: The study included 71 children with AHO, 56% male, with a median age of 3 years (interquartile range, 1–11). We found a 1.8-fold increase of cases in the last 5 years. The causative agent was identified in 37% of cases: MSSA (54%), MRSA (4%), Streptococcus pyogenes (19%), Kingella kingae (12%), Streptococcus pneumoniae (8%), and Neisseria meningitidis (4%). Complications were identified in 45% of patients and sequelae in 3.6%. In recent years, there was an increase in myositis (30% vs. 7%; p = 0.02), septic arthritis (68% vs. 37.2%; p = 0.012) and in the proportion of patients treated for less than 4 weeks (37% vs. 3.5%; p = 0.012), with a similar sequelae rates. The risk factors for complications were age 3 or more years, CRP levels of 20 mg/l or higher, time elapsed between onset and admission of 5 or more days and positive culture, although on multivariate analysis only positive culture was significant. The presence of complications was a risk factor for sequelae at 6 months. Conclusions: Our study confirms that AHO can be aggressive. The identification of risk factors for complications may be fundamental for management.
