Author(s):
Roque, Ana Cecília Afonso ; Pina, Ana Sofia ; Azevedo, Ana Margarida ; Aires-Barros, Raquel ; Jungbauer, Alois ; Di Profio, Gianluca ; Heng, Jerry Y. Y. ; Haigh, Jonathan ; Ottens, Marcel
Date: 2020
Persistent ID: http://hdl.handle.net/10362/141850
Origin: Repositório Institucional da UNL
Project/scholarship:
info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F97585%2F2013/PT;
Subject(s): aqueous-two phase systems; continuous and integrated processes; crystallization; high throughput process development; membrane technology; non-conventional chromatography; Applied Microbiology and Biotechnology; Molecular Medicine
Description
PTDC/BII-BIO/28878/2017 UIDB/04378/2020 UID/BIO/04565/2020 POCI-01-0145-FEDER-007728 LISBOA-01-0145-FEDER-028878 Future Fellowship (EP/N015916/1) Sem PDF conforme despacho.
While packed bed chromatography, known as conventional chromatography, has been serving the biopharmaceutical industry for decades as the bioseparation method of choice, alternative approaches are likely to take an increasing leading role in the next few years. The high number of new biological drugs under development, and the need to make biopharmaceuticals widely accessible, has been driving the academia and industry in the quest of anything but conventional chromatography approaches. In this perspective paper, these alternative approaches are discussed in view of current and future challenges in the downstream processing field.
