Author(s):
Louro, Henriqueta ; Gomes, Bruno Costa ; Saber, Anne Thoustrup ; Iamiceli, Anna Laura ; Göen, Thomas ; Jones, Kate ; Katsonouri, Andromachi ; Neophytou, Christiana M ; Vogel, Ulla ; Ventura, Célia ; Oberemm, Axel ; Duca, Radu Corneliu ; Fernandez, Mariana F ; Olea, Nicolas ; Santonen, Tiina ; Viegas, Susana ; Silva, Maria João
Date: 2022
Persistent ID: http://hdl.handle.net/10362/143634
Origin: Repositório Institucional da UNL
Subject(s): effect biomarker; exposure biomarker; human biomonitoring; occupational exposure; polycyclic aromatic hydrocarbons; Health, Toxicology and Mutagenesis; Toxicology; Chemical Health and Safety; SDG 3 - Good Health and Well-being
Description
Funding: This project has received funding from the European Unions’ Horizon 2020 research and innovation Programme under grant agreement No 733032. HBM4EU.
Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.
