Author(s):
Ferreira, Alexandre Oliveira ; Reves, Joana Branco ; Nascimento, Catarina ; Frias-Gomes, Catarina ; Costa-Santos, Maria Pia ; Ramos, Lídia Roque ; Palmela, Carolina ; Gloria, Luísa ; Cravo, Marília ; Dinis-Ribeiro, Mário ; Canena, Jorge
Date: 2023
Persistent ID: http://hdl.handle.net/10362/147231
Origin: Repositório Institucional da UNL
Subject(s): Adenoma; Chromoendoscopy; Colonoscopy; Narrow band imaging; Quality; Sessile serrated lesion; Gastroenterology; SDG 3 - Good Health and Well-being
Description
Funding Information: The authors would like to acknowledge the support of the Portuguese Society of Gastroenterology by granting the use of the REDCap software. Study data were collected and managed using REDCap (Research Electronic Data Capture) tools hosted at Sociedade Portuguesa de Gastrenterologia. REDCap is a secure, Web-based software platform designed to support data capture for research studies, providing (1) an intuitive interface for validated data capture; (2) audit trails for tracking data manipulation and export procedures; (3) automated export procedures for seamless data downloads to common statistical packages; and (4) procedures for data integration and interoperability with external sources. Publisher Copyright: © 2022 The Author(s). Published by S. Karger AG, Basel.
Background: Colorectal cancer (CRC) is a leading cause of cancer. The detection of pre-malignant lesions by colonoscopy is associated with reduced CRC incidence and mortality. Narrow band imaging has shown promising but conflicting results for the detection of serrated lesions. Methods: We performed a randomized clinical trial to compare the mean detection of serrated lesions and hyperplastic polyps ≥10 mm with NBI or high-definition white light (HD-WL) withdrawal. We also compared all sessile serrated lesions (SSLs), adenoma, and polyp prevalence and rates. Results: Overall, 782 patients were randomized (WL group 392 patients; NBI group 390 patients). The average number of serrated lesions and hyperplastic polyps ≥10 mm detected per colonoscopy (primary endpoint) was similar between the HD-WL and NBI group (0.118 vs. 0.156, p = 0.44). Likewise, the adenoma detection rate (55.2% vs. 53.2%, p = 0.58) and SSL detection rate (6.8% vs. 7.5%, p = 0.502) were not different between the two study groups. Withdrawal time was higher in the NBI group (10.88 vs. 9.47 min, p = 0.004), with a statistically nonsignificant higher total procedure time (20.97 vs. 19.30 min, p = 0.052). Conclusions: The routine utilization of narrow band imaging does not improve the detection of serrated class lesions or any pre-malignant lesion and increases the withdrawal time.
