Author(s): Coelho, Luís ; Falcão, Fatima ; Povoa, Pedro ; Viegas, Erica ; Martins, Antonio Pais ; Carmo, Eduarda ; Fonseca, Candida ; Campos, Luis ; Mansinho, Kamal ; Carmo, Inês ; Soares, Joana ; Solano, Mariana ; Mendes, Dina ; Miranda, Ana Cláudia ; Carvalho, Antonio ; Mirco, Ana ; Farinha, Helena ; Aldir, Isabel ; Correia, José
Date: 2023
Persistent ID: http://hdl.handle.net/10362/151476
Origin: Repositório Institucional da UNL
Subject(s): General
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Coronavirus disease 2019 (COVID-19) is a pandemic infection caused by the newly discovered severe acute respiratory syndrome coronavirus 2. Remdesivir (RDV) and corticosteroids are used mainly in COVID-19 patients with acute respiratory failure. The main objective of the study was to assess the effectiveness of remdesivir with and without corticosteroids in the treatment of COVID-19 patients. We conducted a prospective observational study, including adult patients consecutively hospitalized with confirmed COVID-19 and acute respiratory failure. Patients were divided according to treatment strategy: RDV alone versus RDV with corticosteroids. The primary outcome was the time to recovery in both treatment groups. We included 374 COVID-19 adult patients, 184 were treated with RDV, and 190 were treated with RDV and corticosteroid. Patients in the RDV group had a shorter time to recovery in comparison with patients in the RDV plus corticosteroids group at 28 days after admission [11 vs. 16 days (95% confidence Interval 9.7-12.8; 14.9-17.1; p = .016)]. Patients treated with RDV alone had a shorter length of hospital stay. The use of corticosteroids as adjunctive therapy of RDV was not associated with improvement in mortality of COVID-19 patients.
