Author(s):
Bero, Diocreciano Matias ; da Silva, Edson Elias ; Júnior, Ivanildo Pedro de Sousa ; Nhassengo, Sheila António ; Machado, Raiana Scerni ; Bauhofer, Adilson Fernando Loforte ; Chilaúle, Jorfélia José ; Munlela, Benilde ; Guimarães, Esperança ; Cossa-Moiane, Idalécia ; Sambo, Júlia ; Anapakala, Elda ; Cassocera, Marta ; Coutinho-Manhique, Lena ; Chissaque, Assucênio ; Langa, Jerónimo S. ; Burlandy, Fernanda ; de Deus, Nilsa
Date: 2023
Persistent ID: http://hdl.handle.net/10362/154766
Origin: Repositório Institucional da UNL
Subject(s): Children; Diarrheal disease; Enterovirus; Gastroenteritis; Mozambique; RA0421 Public health. Hygiene. Preventive Medicine; RJ101 Child Health. Child health services; Infectious Diseases; Virology; Pediatrics, Perinatology, and Child Health; Gastroenterology; SDG 3 - Good Health and Well-being; SDG 10 - Reduced Inequalities
Description
Funding Information: Diocreciano Bero, Ph.D. was supported by Brazilian National Council for Scientific and Technological Development and the Academy of Sciences for the Developing World (CNPq/TWAS, grant number 190,897/2015–5). The ViNaDia was sponsored by Gavi, the Vaccine Alliance through Centers for Disease Control and Prevention (CDC) , Atlanta and World Health Organization, Regional Office for Africa (WHO/AFRO), Deutsche Forschungsgemeinschaft (DFG, grant number JO369/5–1). Nilsa de Deus was fellowship of the European Foundation Initiative into African Research in Neglected Tropical Diseases (EFINTD, grant number 89,539). Publisher Copyright: © 2022
Enteroviruses (EV) are predominantly enteric viruses, present in all parts of the world causing disease in humans with a broad spectrum of clinical presentations. The purpose of this study was to identify non-polio enteroviruses (NPEV) in stool samples collected from children with acute gastroenteritis (AGE) symptoms of unknown etiology in four provinces (Maputo, Nampula, Sofala and Zambézia) of Mozambique. From June 2014 to March 2018, 327 stool samples were collected from children hospitalized with AGE in health care units. NPEVs were detected in 52 samples (52/327; 15.9%) and were more frequent in children under 5 years of age. The age group from 12 to 23 months was the most affected and showed more severity of disease. We also identified 26 different EV-types with the following detection pattern EV-B>EV-C>EV-A. The major EV-types were EV-A119 (9/52; 17.3%) and EV-C99 (8/52; 15.4%), accounting for 32.7% of the total. In addition to EV-A119, other uncommon EV-types were also identified, such as EV-B75, EV-B97 and EV-C113. The current study shows a high heterogeneity of EV types circulating in children with AGE in Mozambique as well as the identification of rarely described enteroviruses.
