Autor(es):
Georgiadis, Stylianos ; Ørnbjerg, Lykke Midtbøll ; Michelsen, Brigitte ; Kvien, Tore K. ; Giuseppe, Daniela Di ; Wallman, Johan K. ; Závada, Jakub ; Provan, Sella A. ; Kristianslund, Eirik Klami ; Rodrigues, Ana Maria ; Santos, Maria José ; Rotar, Žiga ; Pirkmajer, Katja Perdan ; Nordström, Dan ; Macfarlane, Gary J. ; Jones, Gareth T. ; van der Horst-Bruinsma, Irene ; Hellamand, Pasoon ; Østergaard, Mikkel ; Hetland, Merete Lund
Data: 2024
Identificador Persistente: http://hdl.handle.net/10362/169887
Origem: Repositório Institucional da UNL
Assunto(s): axial spondyloarthritis; patient outcome assessment; registry data; validation study; Rheumatology; Immunology and Allergy; Immunology
Descrição
Funding Information: On behalf of the EuroSpA Scientific Committee, the authors acknowledge Novartis Pharma AG and IQVIA for supporting the EuroSpA Research Collaboration Network. Publisher Copyright: © 2024 The Journal of Rheumatology.
Objective. Ankylosing Spondylitis Disease Activity Score based on C-reactive protein (ASDAS-CRP) is recommended over ASDAS based on erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs (1.3, 2.1, and 3.5) and investigate the potential improvement of level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states when applying these estimated cut-offs. Methods. We used data from patients with axSpA from 9 European registries initiating a tumor necrosis factor inhibitor. ASDAS-ESR cut-offs were estimated using the Youden index. The level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states was compared against each other. Results. In 3664 patients, mean ASDAS-CRP was higher than ASDAS-ESR at both baseline (3.6 and 3.4, respectively) and aggregated follow-up at 6, 12, or 24 months (1.9 and 1.8, respectively). The estimated ASDAS-ESR values corresponding to the established ASDAS-CRP cut-offs were 1.4, 1.9, and 3.3. By applying these cut-offs, the proportion of discordance between disease activity states according to ASDAS-ESR and ASDAS-CRP decreased from 22.93% to 19.81% in baseline data but increased from 27.17% to 28.94% in follow-up data. Conclusion. We estimated the optimal ASDAS-ESR values corresponding to the established ASDAS-CRP cut-off values. However, applying the estimated cut-offs did not increase the level of agreement between ASDAS-ESR and ASDAS-CRP disease activity states to a relevant degree. Our findings did not provide evidence to reject the established cut-off values for ASDAS-ESR.
