Author(s):
Monteiro, Vânia ; Dias da Silva, Diana ; Martins, Marta ; Guedes de Pinho, Paula ; Pinto , Joana
Date: 2024
Persistent ID: http://hdl.handle.net/10362/172267
Origin: Repositório Institucional da UNL
Project/scholarship:
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT;
info:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0069%2F2020/PT;
info:eu-repo/grantAgreement/FCT/CEEC INST 2ed/CEECINST%2F00108%2F2021%2FCP2794%2FCT0001/PT;
Subject(s): Ecotoxicological effects; Environmental contaminants; Metabolomics approaches; Multiple PAH interactions; Polycyclic aromatic hydrocarbons (PAHs); Biochemistry; Environmental Science(all)
Description
This research was funded by national funds from FCT-Fundação para a Ciência e a Tecnologia, I.P., in the scope of the PAHMIX project - Mixtures of Environmental Carcinogens: a molecular approach to improve environmental risk assessment strategies (PTDC/CTA- AMB /29,173/2017). Publisher Copyright: © 2024 The Authors
Polycyclic Aromatic Hydrocarbons (PAHs) represent persistent environmental pollutants ubiquitously distributed in the environment. Their presence alongside various other contaminants gives rise to intricate interactions, culminating in profound deleterious consequences. The combination effects of different PAH mixtures on biota remains a relatively unexplored domain. Recent studies have harnessed the exceptional sensitivity of metabolomic techniques to unveil the significant ecotoxicological perils of PAH pollution confronting both human populations and ecosystems. This article furnishes a comprehensive overview of current literature focused on the metabolic repercussions stemming from exposure to complex mixtures of PAHs or PAH-pollution sources using metabolomics approaches. These insights are obtained through a wide range of models, including in vitro assessments, animal studies, investigations on human subjects, botanical specimens, and soil environments. The findings underscore that PAH mixtures induce cellular stress responses and systemic effects, leading to metabolic dysregulations in amino acids, carbohydrates, lipids, and other key metabolites (e.g., organic acids, purines), with specific variations observed based on the organism and PAH compounds involved. Additionally, the ecological consequences of PAH pollutants on plant and soil microbial responses are emphasized, revealing significant changes in stress-related metabolites and nutrient cycling in soil ecosystems. The complex interplay of various PAHs and their metabolic effects on several models, as elucidated through metabolomics, highlight the urgency of further research and the need for comprehensive strategies to mitigate the risks posed by these widespread environmental pollutants.
