Autor(es): Medeiros, Mariana Silva ; Botelho de Carvalho, Luís André ; Alves, Marta ; Papoila, Ana ; Baptista Carreira dos Santos, Hugo Miguel ; Capelo-Martínez, José Luis ; Pinheiro, Luís Manuel Viegas de Campos
Data: 2024
Identificador Persistente: http://hdl.handle.net/10362/173273
Origem: Repositório Institucional da UNL
Assunto(s): CUBN/MPO; Non-muscle-invasive bladder cancer; Recurrence; Urinary proteome; Nephrology; Urology; SDG 3 - Good Health and Well-being
Publisher Copyright: © The Author(s) 2024. Open access funding provided by FCT|FCCN (b-on).
Purpose: T1 bladder cancer is known for its high progression and recurrence rates. Identifying aggressive tumours at the non-muscle-invasive stage is crucial to allow early interventions and subsequently increase patient survival. This study aimed to investigate the potential of the cubilin/myeloperoxidase (CUBN/MPO) ratio as a high-grade T1 bladder cancer biomarker. Methods: Urine samples were collected from 30 patients who underwent transurethral resection of the tumour with high-grade T1 bladder cancer (June 2015 to December 2019) before surgery. The urinary proteome was analysed using high-resolution mass spectrometry and the CUBN/MPO ratio was calculated. The primary outcome was the recurrence during the follow-up (around 31.5 months after resection). Univariate Cox regression and Kaplan–Meier curves were used for data analysis. Results: Patients with a low CUBN/MPO ratio exhibited upregulated MPO and/or downregulated CUBN. This group of patients had a higher incidence of disease recurrence and progression. Low CUBN/MPO ratio was significantly associated with a higher likelihood of recurrence, progression, and death. It is worth noting that this study was exploratory and conducted on a small sample size, so further research is needed to validate these findings in larger cohorts. Conclusion: This study highlights the potential of the CUBN/MPO ratio as a prognostic biomarker for high-grade T1 bladder cancer.
