Autor(es):
Namorado, Sónia ; Martins, Carla ; Ogura, Joana ; Assunção, Ricardo ; Vasco, Elsa ; Appenzeller, Brice ; I Halldorsson, Thorhallur ; Janasik, Beata ; Kolossa-Gehring, Marike ; Van Nieuwenhuyse, An ; Ólafsdóttir, Kristin ; Rambaud, Loïc ; Riou, Margaux ; Silva, Susana ; Wasowicz, Wojciech ; Weber, Till ; Esteban-López, Marta ; Castaño, Argelia ; Gilles, Liese ; Rodríguez Martin, Laura ; Govarts, Eva ; Schoeters, Greet ; Viegas, Susana ; Silva, Maria João ; Alvito, Paula
Data: 2024
Identificador Persistente: http://hdl.handle.net/10362/176468
Origem: Repositório Institucional da UNL
Assunto(s): Chemical exposure; Deoxynivalenol; HBM4EU; Human biomonitoring; Mycotoxins; Risk assessment; Food Science; SDG 3 - Good Health and Well-being
Descrição
Funding Information: HBM4EU has received funding from the European Union\u2019s research and innovation programme Horizon 2020 under grant agreement No. 733032. The HBM4EU Aligned Studies were co-funded by the European Union\u2019s programme Horizon 2020 through HBM4EU and by the participating countries through the co-authors organizations. Publisher Copyright: © 2024 The Authors
Mycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the internal exposure of the adult European population and identify the most relevant determinants of exposure. tDON concentrations’ P50 and P95 were in the range of 0.41–10.16 µg/L (0.39–9.05 µg/g crt) and 3.25–46.58 µg/L (2.12–33.50 µg/g crt) respectively. Higher tDON levels were observed for (i) male participants from France and Germany, (ii) samples collected in spring and summer, (iii) participants with a lower educational level, (iv) participants living in rural areas, (v) individuals without a job in France and Luxembourg, while in Portugal higher exposure was observed in working individuals, (vi) individuals with higher consumption of cereals and bread. The proportion of individuals with exposure levels exceeding the HBM-GV of 23 µg/L was 12.3 %, ranging from 0.8 % to 20.7 % in the individual countries. This study on mycotoxins exposure has used post harmonized questionnaire data and validated analytical methodologies for analysis and covered countries representing the four geographical regions of Europe, having produced much needed knowledge on the exposure of the European adult population to deoxynivalenol.
