Structural characterization of mycobacterial arabinofuranosyltransferases

• Author(s): Rodrigues, José
• Date: 2024
• Persistent ID: http://hdl.handle.net/10362/176871
• Origin: Repositório Institucional da UNL
• Subject(s): arabinofuranosyltransferases; tuberculosis; synthesis; therapeutics; membrane proteins
• Document Type: Doctoral thesis
• Language: English
• Advisor(s): Archer, Margarida
• Contributor(s): RUN

Description

"Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis and is one of the most ancient infectious diseases known to affect mankind. In fact, still to this day, TB is one of the leading causes of death worldwide, as it is estimated that around 1.3 – 1.5 million people die from TB and 10 million new cases appear, every year. In addition, about 370,000 to 450,000 people develop multidrug-resistant TB (MDR-TB), for which the treatment regimens are longer and present lower success rates.(...)"

This research was supported by Fundação Luso-Americana para o Desenvolvimento (FLAD) through a fellowship attributed to José Rodrigues (Proj.166/2017) and funding attributed to Dr. Margarida Archer.