Assessing tumour-associated macrophage phenotype and glycan signatures in breast cancer: Insights from 3D cell models and protein microarrays

• Autor(es): Lopes, Nuno
• Data: 2025
• Identificador Persistente: http://hdl.handle.net/10362/181282
• Origem: Repositório Institucional da UNL
• Projeto/bolsa: info:eu-repo/grantAgreement/FCT//2020.07623.BD/PT; info:eu-repo/grantAgreement/FCT/Concurso de Projetos IC&DT em Todos os Domínios Científicos/PTDC%2FBTM-TEC%2F0432%2F2021/PT
• Assunto(s): 3D cancer models; tumor-associated macrophages; antibody-drug conjugates; targeted therapies; cancer-associated fibroblasts
• Tipo de Documento: Tese de doutoramento
• Idioma: Inglês
• Orientador(es): Brito, Catarina; Palma, Ângela
• Contribuidor(es): RUN

Descrição

"Breast cancer (BC) remains the cancer type with highest incidence in women, being the leading cause of cancer-related mortality. Among all subtypes, triple negative BC (TNBC) presents the worst prognosis, with the highest rates for recurrence and progression. Despite the dire scenario for TNBC, scarce therapeutic options are available, relying primarily on chemotherapy. In past years, the immune microenvironment has been recognised as an attractive strategy to target TNBC. High infiltrates of tumour-associated macrophages (TAMs), particularly, have been reported in TNBC, mediating immunosuppressive events.(...)"