A 3D hepatic model to address immune‐mediated drug hepatotoxicity

• Author(s): Oliveira, Jhenifer
• Date: 2021
• Persistent ID: http://hdl.handle.net/10362/186889
• Origin: Repositório Institucional da UNL
• Subject(s): Liver; 3D culture; macrophages; Kupffer cells; inflammation; HepG2 cells
• Document Type: Master thesis
• Language: English
• Contributor(s): RUN

Description

"The liver is a complex organ involved in many important physiological functions. Several hepatic diseases, such as alcohol-related liver disease and drug-induced hepatotoxicity, are associated with liver inflammation. Thus, it is of extreme relevance to understand the mechanisms involved in liver inflammation to develop the best strategies to fight these diseases. The hepatic macrophages, resident Kupffer cells and monocyte-derived macrophages, are known to play a critical role in the liver inflammatory response. Although the diversity of experimental models available to address hepatic diseases has been growing, there is still a need for models that can depict the contribution of macrophages to the inflammatory response upon injury.(...)"