Prevention of retinopathy of prematurity

• Autor(es): Fortes Filho,João Borges ; Eckert,Gabriela Unchalo ; Tartarella,Marcia Beatriz ; Procianoy,Renato Soibelmann
• Data: 2011
• Origem: Oasisbr
• Assunto(s): Retinopathy of prematurity; Blindness/prevention & control; Risk factors
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

Retinopathy of prematurity (ROP) is related to oxygen-regulated vascular endothelial growth factor and to insulin-like growth factor-I. After premature birth, supplemental oxygen induces a retinal hyperoxic condition with vasoconstriction and to a definitive interruption of retinal vasculogenesis. Peripheral ischemia may stimulate retinal neovascularization and the onset of additional ROP-related complications. The natural course of the disease may result in irreversible blindness if not promptly diagnosed and attended. Recently, a significant increase in the prevalence of ROP has been observed in survival rates of preterm infants, especially in emerging-economy countries in Latin America, Asia, and Eastern Europe. This article addresses the main preventive measures in ROP.