Author(s): Fiorot Júnior,José Antonio ; Felício,André Carvalho ; Fukujima,Márcia Mauimi ; Rodrigues,Celso Arraes ; Morelli,Vânia Maria ; Lourenço,Dayse Maria ; Prado,Gilmar Fernandes do
Date: 2005
Origin: Oasisbr
Subject(s): cerebral venous thrombosis; tuberculosis; prothrombin gene mutation
Several infectious etiologies are related to cerebral venous thrombosis (CVT), but a review of literature showed only few cases related to tuberculosis (TB), and only one with neurological manifestations.We report an unusual case of CVT related to TB and mutation in prothrombin gene. A 38-man black presented abrupt right hemiparestesis, and hemiparesis. Investigations revealed CVT. Cerebral spinal fluid (CSF) examination evidenced a infection by Mycobacterium. He was heterozygous for G20210A prothrombin mutation. Probably, hypercoagulability mechanisms of TB, added to mutation of prothrombim gene increase the risk of CVT.
