Author(s): Gomes,Maria Antonia Ferreira ; Medeiros,Lana Lira Cantidio de ; Lobo,Fernanda Paula Dantas ; Wanderley,Nathália Rayane Silva ; Matos,Ana Paula Rodrigues ; Jácome,Tácito do Nascimento ; Monteiro,Maria Goretti Lins ; Luz,Kleber Giovanni
Date: 2018
Origin: Oasisbr
Subject(s): Visceral leishmaniasis; Refractory; Treatment
Abstract Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.
