Uso da FTIR na obtenção de resinas e na síntese de peptídeos em fase sólida

• Autor(es): Cespedes,Graziely Ferreira ; Vicente,Eduardo Festozo ; Cilli,Eduardo Maffud ; Jubilut,Guita Nicolaewsky ; Nakaie,Clovis Ryuichi
• Data: 2011
• Origem: Oasisbr
• Assunto(s): FTIR; SPPS; resin
• Tipo de Documento: Artigo científico
• Idioma: Português

Descrição

Despite the increase in peptide chain aggregation, which decreases the rate of coupling reactions, the synthesis and use of very highly substituted resins still remains as a controversial point in the SPPS, due to its clear economical advantages (lesser solvent consumption and higher amount of peptide per synthesis). In order to better investigate the synthesis and the use of very highly substituted resins, the FTIR, NMR and EPR were compared. By FTIR techniques it was possible to follow all the steps of resin synthesis and the factors affecting the aggregation of the chains inside the peptidil-BHAR and MBHAR.