Author(s): Sartorelli,Patricia ; Santana,Jefferson S. ; Guadagnin,Rafael C. ; Lago,João Henrique G. ; Pinto,Érika G. ; Tempone,André G. ; Stefani,Hélio A. ; Soares,Marisi G. ; Silva,Adalberto M. da
Date: 2012
Origin: Oasisbr
Subject(s): Schinus terebinthifolius Raddi; Anacardiaceae; trypanocidal activity
Essential oils of ripe fruits from Schinus terebinthifolius (Anacardiaceae), obtained using a pilot extractor and a Clevenger apparatus were chemically characterized. Due the high amount of (-)- α-pinene in both oils, this monoterpene was tested against the protozoan parasite Trypanosoma cruzi, showing a moderate potential (IC50 63.56 µg/mL) when compared to benznidazole (IC50 43.14 µg/mL). Otherwise, (-)- α-pinene oxide did not showed anti-trypanosomal activity (IC50 > 400 µg/mL) while (-)-pinane showed an IC50 of 56.50 µg/mL. The obtained results indicated that the epoxydation of α-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
