Autor(es): Polonini,Hudson C. ; Soldati,Pedro Paulo ; Oliveira,Marcone Augusto Leal de ; Brandão,Marcos Antônio F. ; Chaves,Maria das Graças M. ; Raposo,Nádia R. B.
Data: 2014
Origem: Oasisbr
Assunto(s): in vitro dug release; transdermal steroids; semi-solid formulations
In vitro release of bioidentical hormones in four different liposomal transdermal emulsions (containing testosterone, progesterone, estradiol, or estradiol and estriol) was assessed. For this purpose, novel high-performance liquid chromatography methods were developed and validated in an eco-friendly manner and used to determine the in vitro release of such products. The methods were suitable for our intended goal, and the emulsions employed were found to be effective as transporting candidates for the efficient release of hormones in the transdermal delivery of human sexual steroids.
