Autor(es): Campelo,Ana Paula Bomfim Soares ; Campelo,Márcio Wilker Soares ; Brito,Gerly Anne de Castro ; Jamacaru,Francisco Vagnaldo Fechine ; Leitão,Renata Ferreira de Carvalho ; Vasconcelos,Paulo Roberto Leitão de
Data: 2015
Origem: Oasisbr
Assunto(s): Burn; Fatty Acids; Seaweed; Docosahexenoic Acid. alpha-Linolenic Acid; Rats
PURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury.METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (ALA + DHA from seaweed). The thermal injury was involving total thickness of skin. After the burns animals received the oil mixes for seven days. The lesions were evaluated by immunohistochemistry.RESULTS:Animals receiving mix 3 showed a smaller extension of the thermal injury as compared to those that were supplemented with other oils mixes. Expression of Ki-67 in the receiving Mix 3 increased as compared to all the other groups. Animals supplemented with mix 3 were able to inhibit NF-κB in injured tissue.CONCLUSION:Rats received oil mix in which the source of ω3 (ALA+DHA of seaweed) showed inhibition of NF-κB, increase in cell proliferation, and reduction the extension of thermal lesion.
