Author(s): Macêdo,Clóvis Ney Pinheiro ; Braga,Francisco Evanilso Silva ; Campelo,Ana Paula Bomfim Soares ; Diniz,Gabriel Maia ; Lopes,Luiz Gonzaga de França ; Kubrusly,Marcos ; Campelo,Marcio Wilker Soares
Date: 2019
Origin: Oasisbr
Subject(s): Anti-Inflammatory Agents, Non-Steroidal; Kidney; Ruthenium; Rats
Abstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals – 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
