Synthesis of Ent-16-hydroxycleroda-4(18),13-dien-15,16-olide and Ent-cleroda-4(18),13-dien-15,16-olide from (+)-hardwickiic acid

• Author(s): Ide,Regina M. ; Costa,Marta ; Imamura,Paulo M.
• Date: 2006
• Origin: Oasisbr
• Subject(s): (+)-hardwickiic acid; clerodane; butenolide; absolute configuration
• Document Type: Journal article
• Language: English

Description

The absolute configurations of two natural diterpene butenolides were confirmed through the synthesis of ent-16-hydroxycleroda-4(18),13-dien-15,16-olide (2) and ent-cleroda-4(18),13-dien-15,16-olide (3), enantiomers of the natural products, starting from (+)-hardwickiic acid (1).