Author(s): Teixeira,Fátima C. ; Lucas,Carla ; Curto,M. João M. ; Neves,M. ; Duarte,M. Teresa ; André,Vânia ; Teixeira,António P. S.
Date: 2013
Origin: Oasisbr
Subject(s): bisphosphonates; 1H-pyrazolo[3,4-b]pyridine; spectroscopic characterization; synthesis; X-ray diffractometry studies
A number of 1H-pyrazolo[3,4-b]pyridine derivatives, starting from 2-chloro-3-formyl pyridine, was synthesized to obtain new 1-hydroxybisphosphonates, a class of compounds with potential biological interest. Spectroscopic data were used to characterize all compounds and to identify N-1 and N-2 regioisomers, and mono-and bisphosphonates derivatives. X-ray diffractometry studies of compound 7a confirmed the proposed structure.
