Author(s): Ávila,Fábio N. ; Pinto,Francisco C. L. ; Sousa,Thiciana S. ; Torres,Maria Conceição M. ; Costa-Lotufo,Leticia V. ; Rocha,Danilo D. ; Vasconcelos,Mayron A. de ; Cardoso-Sá,Nairley ; Teixeira,Edson H. ; Albuquerque,Maria Rose Jane R. ; Silveira,Edilberto R. ; Pessoa,Otília D. L.
Date: 2017
Origin: Oasisbr
Subject(s): Plectranthus ornatus; diterpenes; ent-clerodanes; bacteriostatic
Five new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of analogous compounds. All isolated compounds were assayed against four human cancer cell lines, and Gram-positive and Gram-negative bacteria strains. None of them showed any cytotoxic activity, but ornatin C, D, E and three related diterpenes displayed marginal bactericidal or bacteriostatic effects against the Gram-positive strains.
