Author(s): Bressan,Aline Lopes ; Pereira,Daniele ; Medeiros,Paula Mota ; Carneiro,Sueli ; Azulay-Abulafia,Luna
Date: 2017
Origin: Oasisbr
Subject(s): Capillary permeability; Endothelial growth factors; Endothelium, vascular; Psoriasis; Vascular endothelial growth factor, endocrine-gland-derived
Abstract: Psoriasis is a chronic disease, characterized by erythematous scaly lesions, presented in eight different forms: plaques, guttate, pustular, erythrodermic, inverse, nail and scalp psoriasis, and psoriatic arthritis. Its development depends on genetic factors, external stimulus and immune response alteration.1 Proinflammatory cytokines such as TNF-alpha, IL-12 and 23 may also be involved. In the worst cases, systemic complications linked to endothelial alterations may occur. A literature review was conducted for a better understanding of what roles VEGF (vascular endothelial growth factor) and ICAM-1 (intercellular adhesion molecule) have, among other cytokines, in systemic capillary leak syndrome, involved in erythrodermic and pustular psoriasis, the most unstable forms of the disease.
