Author(s): Grecco,Marcelle ; Santos,Viviane Cardoso dos ; Pereira,Kaline Medeiros Costa ; Andrade,Luís Eduardo Coelho ; Silva,Neusa Pereira da
Date: 2016
Origin: Oasisbr
Subject(s): Systemic lupus erythematosus; Fc gamma receptor IIIa; Single nucleotide polymorphism; Gene polymorphism; Immunogenetics
ABSTRACT We evaluated the possible association between FCGR3A V/F (158) polymorphism and SLE susceptibility and clinical phenotype in 305 sequentially retrieved SLE patients and 300 healthy controls from the southeastern part of Brazil by allele-specific polymerase chain reaction. Our results showed no association between FCGR3A 158V/F alleles and susceptibility to SLE in this series of patients albeit the heterozygous genotype was strongly associated with the disease.
