Author(s): Murinello,António ; Tomé,Teresa ; Goulão,Augusto ; Cohen,Álvaro
Date: 2010
Origin: SciELO Portugal
Subject(s): Wilsons disease; zinc; corpus callosum agenesis; hypocupremia
Document details
Zinc therapy of neurological Wilsons disease in a woman with two foetus with agenesis of the corpus callosum
Description
CLINICAL REPORT: A patient diagnosed Wilsons disease (WD) 22 years previously, successfully treated initially with zinc, developed neuropsychiatric disease after years of irregular therapy. Reassuming zinc therapy was successful. After a normal pregnancy, she had two therapeutic abortions for corpus callosum agenesis, and a missed abortion. We review the genetics, physiopathology, clinics and imagiologic response to zinc therapy, the problems of pregnancy in WD, advising to maintain therapy. A hypothetic cause for fetus brain anomaly would be hypocupremia due to zinc therapy, confronting with two other possibilities, one related to Wilsons disease in itself, other due to a congenital syndrome of agenesis of the corpus callosum, impossible to diagnose by our available diagnostic methods.
Document Type
Report
Language English
Language English
