Autor(es): Wainberg,Milton L. ; Mann,Claudio G. ; Norcini-Pala,Andrea ; McKinnon,Karen ; Pinto,Diana ; Pinho,Veronica ; Cavalcanti,Maria T. ; Cheng-Shiun,Leu ; Guimarães,Mark D. ; Mattos,Paulo ; Hughes,Elizabeth ; Palinkas,Lawrence A. ; Otto-Salaj,Laura ; Remien,Robert H. ; Cournos,Francine
Data: 2020
Origem: Oasisbr
Assunto(s): Prevention; intervention study; behavioral research; treatment efficacy; program effectiveness
Objective: Human immunodeficiency virus (HIV) prevention efficacy trials with psychiatric patients have been conducted in research settings in high-resourced countries, establishing short-term efficacy for reducing sexual risk behavior. None has been implemented within systems of care. In the last decade, overcoming this research-to-practice gap has become a focus of implementation science. This paper describes the first and only HIV Prevention intervention trial for psychiatric patients conducted in real-world outpatient psychiatric settings facilitated by trained clinic-based providers. Methods: The HIV Prevention intervention, which uses the Information-Motivation-Behavioral Skills model to achieve sexual risk-reduction, was rigorously adapted to the local context and clinic services’ needs. Participants from eight clinics were randomized to HIV Prevention or Health Promotion conditions. Results: HIV Prevention participants showed significant improvement in Information-Motivation-Behavioral domains; in this group, behavioral intentions were associated with significantly fewer unprotected sex occasions, but reduction of unprotected sex occasions was similar in both conditions. Conclusion: Our trial was conducted before implementation studies became widely funded. Transporting an intervention to a new culture or into real-world practice settings may require adaptations. Our results demonstrate that clear guidelines are needed regarding whether to conduct efficacy, effectiveness, and/or implementation research as the most appropriate next step. Clinical trial registration: NCT00881699
