Autor(es): Custodio,Luiz Antonio ; Saito,Alexandre ; Amarante,Marla Karine ; Fujita,Thiago Cezar ; Perim,Aparecida de Lourdes ; Costa,Ivete Conchon ; Felipe,Ionice ; Jankevicius,Shiduca Itow
Data: 2012
Origem: Oasisbr
Assunto(s): Mycobacterium leprae; leprosy; hanseniase; nasal mucus; PCR
In the present study, nasal mucus from patients with leprosy were analyzed by PCR using specific primers for Lsr2 gene of Mycobacterium leprae. The presence of Lsr2 gene in the nasal mucus was detected in 25.80% of patients with paucibacillari leprosy, and 23.07% of contacts. Despite the absence of clinical features in the contact individuals, it was possible to detect the presence of Lsr2 gene in the nasal mucus of these individuals. Therefore, PCR detection of M. leprae targeting Lsr2 gene using nasal mucus samples could contribute to early diagnosis of leprosy.
