Autor(es): Abrahão,Agessandro ; Dutra,Livia Almeida ; Braga Neto,Pedro ; Pedroso,José Luiz ; Oliveira,Ricardo Araújo de ; Barsottini,Orlando Graziani Povoas
Data: 2011
Origem: Oasisbr
Assunto(s): multiple system atrophy; cognitive impairment; dementia; atypical parkinsonism; neuropsychological evaluation.
Abstract Multiple system atrophy (MSA) is characterized by a variable combination of cerebellar ataxia, parkinsonism and pyramidal signs associated with autonomic failure. Classically, cognitive impairment was not considered a clinical feature of MSA and dementia was pointed out as an exclusion diagnostic criteria. Based on comprehensive neuropsychological assessment, cognitive impairment was found to be a frequent feature in MSA, and clinically-defined dementia is now reported in 14-16% of cases. This article reviews the current data on cognitive impairment in MSA along with its neuropsychological profile and pathophysiology.
