Author(s): Comparin,Bruno Cabral ; Santos,Carlos Henrique Marques dos ; Dourado,Doroty Mesquita ; Reichel,Pâmela Micaela Gomes ; Paola,Roberta Silva de ; Pontes,Elenir Rose Jardim Cury
Date: 2018
Origin: Oasisbr
Subject(s): Rats; Rectal fistula; Phytotherapy; Aloe; Therapy
ABSTRACT Rationale: There is a need for a low cost treatment for complex anal fistulas that can heal without causing fecal incontinence, with room for the study of herbal medicines. Objective: To evaluate the effect of the glycerin Aloe barbadensis Miller extract in the treatment of anal fistula in rats. Method: Thirty Wistar rats underwent peritoneal anesthesia with ketamine and Xylasine, followed by transfixation of the anal sphincter with a steel wire, which remained for 30 days to develop the anal fistula. After this period, the steel wire was removed and three groups with 10 animals were formed: A (control), without treatment; B (seton), in which a cotton seton was introduced; C (therapeutic seton), in which a cotton thread was introduced as a seton, and Aloe barbadensis Miller extract was daily dripped in the seton; after 30 days, the setons of groups B and C were removed, and after two weeks without a seton euthanasia and removal of specimens was conducted, and the fistula closure and the inflammatory process were analyzed. Results: Fistula persistence was observed in all animals in Group A, six in Group B and three in Group C (p = 0.015). The mean local inflammation levels were 0.9 in Group A; 0.8 in Group B, and 0 in Group C (p = 0.015). Conclusion: The use of a seton soaked in a glycerin Aloe barbadensis Miller extract was effective in the healing of anal fistulas in rats, in addition to causing less inflammatory process than the non-phytotherapeutic seton.
