Autor(es):
Damiani, Lucas Petri ; Cavalcanti, Alexandre Biasi ; Biond, Rodrigo Santos ; Freitas, Flávio Geraldo Rezende de ; Figueiredo, Rodrigo Cruvinel ; Lovato, Wilson José ; Amêndola, Cristina Prata ; Serpa Neto, Ary ; Paranhos, Jorge Luiz da Rocha ; Veiga, Viviane Cordeiro ; Guedes, Marco Antonio Vieira ; Lúcio, Eraldo de Azevedo ; Oliveira Júnior, Lúcio Couto ; Lisboa, Thiago ; Lacerda, Fabio Holanda ; Miranda, Tamiris Abait ; Maia, Israel Silva ; Grion, Cintia Magalhães Carvalho ; Machado, Flavia Ribeiro ; Zampieri, Fernando Godinho
Data: 2021
Identificador Persistente: http://hdl.handle.net/11690/1897
Origem: Oasisbr
Assunto(s): Balanced solutions; Critical care; Normal saline; Saline solution; Acute kidney injury
Descrição
Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-07-27T19:21:12Z No. of bitstreams: 1 Statistical analysis plan_RBTI.pdf: 252339 bytes, checksum: 5de0c09a4ea278ea11e897b7667d313f (MD5)
Made available in DSpace on 2021-07-27T19:21:12Z (GMT). No. of bitstreams: 1 Statistical analysis plan_RBTI.pdf: 252339 bytes, checksum: 5de0c09a4ea278ea11e897b7667d313f (MD5) Previous issue date: 2020
Objective: To report the statistical analysis plan (first version) for the Balanced Solutions versus Saline in Intensive Care Study (BaSICS). Methods: BaSICS is a multicenter factorial randomized controlled trial that will assess the effects of Plasma-Lyte 148 versus 0.9% saline as the fluid of choice in critically ill patients, as well as the effects of a slow (333mL/h) versus rapid (999mL/h) infusion speed during fluid challenges, on important patient outcomes. The fluid type will be blinded for investigators, patients and the analyses. No blinding will be possible for the infusion speed for the investigators, but all analyses will be kept blinded during the analysis procedure. Results: BaSICS will have 90-day mortality as its primary endpoint, which will be tested using mixed-effects Cox proportional hazard models, considering sites as a random variable (frailty models) adjusted for age, organ dysfunction and admission type. Important secondary endpoints include renal replacement therapy up to 90 days, acute renal failure, organ dysfunction at days 3 and 7, and mechanical ventilation-free days within 28 days. Conclusion: This manuscript provides details on the first version of the statistical analysis plan for the BaSICS trial and will guide the study’s analysis when follow-up is finished.
