Author(s): Antunes, Pedro Miguel da Silva ; Esteves, Dulce ; Nunes, Célia ; Sampaio, Francisco ; Ascensão, António ; Vilela, Eduardo ; Teixeira, Madalena ; Amarelo, Anabela Leal ; Joaquim, Ana
Date: 2019
Persistent ID: http://hdl.handle.net/10400.6/8648
Origin: uBibliorum
Subject(s): Breast cancer; Cardiotoxicity; Cardiac healthcare; Supervised exercise; Supportive cancer care
Anthracyclines are chemotherapeutic agents frequently used in breast cancer (BC) treatment. Although it improves disease-free and overall survival, the use of anthracyclines is associated with a cumulative risk of cardiac toxicity. Preventive strategies to optimize cardiac health are needed and exercise is proposed as a potential non-pharmacological approach for counteracting anthracycline-related cardiotoxicity (ARC). Most of the data on the effects of exercise to reduce ACT are from animal studies, with only a few studies in a limited number of patients indicating beneficial effects. To better understand the effectiveness of exercise in the mitigation of ARC, clinical, real-world trials claim require a larger sample size and more accurate and valuable clinical biomarkers. In this study, we intend to include a large sample and investigate cardiac function through serial measures of biomarkers and imaging techniques.
