Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure

• Author(s): Martins, Sílvia ; Carvalheiro, Tiago ; Laranjeira, Paula ; Martinho, António ; Elvas, Luís ; Gonçalves, Lino ; Tomaz, C. T. ; António, Natália ; Paiva, Artur
• Date: 2019
• Persistent ID: http://hdl.handle.net/10400.6/9219
• Origin: uBibliorum
• Subject(s): Biomarkers; Case-Control Studies; Chronic Heart Failure; Inflammation Mediators; Interleukin-17; Prospective Studies; Th17 Cells; Cardiac Resynchronization Therapy
• Document Type: Journal article
• Language: English
• Contributor(s): uBibliorum

Description

IL-17-producing T cells have been implicated in the inflammatory milieu of chronic heart failure (CHF), which implies a dismal prognosis in affected patients. The aim of this study was to evaluate the impact of cardiac resynchronization therapy (CRT) on the frequency and functional activity of Th17 and Tc17 cells, as well as, on IL-17 mRNA expression in patients with CHF.