New terpenoids from Croton limae (Euphorbiaceae)

• Autor(es): Sousa, Antonio H. ; Silva Junior, José N. ; Guedes, Maria L. S. ; Braz-Filho, Raimundo ; Costa-Lotufo, Letícia V. ; Araújo, Ana J. ; Silveira, Edilberto R. ; Lima, Mary A. S.
• Data: 2016
• Origem: Oasisbr
• Assunto(s): Diterpenos; Diterpenes
• Tipo de Documento: Artigo científico
• Idioma: Inglês

Descrição

An asymmetrical dimer of kaurane diterpene and monoterpene and four novel diterpenes were isolated from the roots of Croton limae, along with kaempferol-3-O-glucoside, ombuin- 3-O-rutinoside and acetyl aleuritolic acid. The cytotoxic activity of the kaurane diterpene was evaluated against colorectal adenocarcinoma (HCT-116), ovarian carcinoma (OVCAR-8) and glioma (SF-295) cell lines, exhibiting IC50 values of 7.14, 8.19 and > 10 µg mL−1, respectively.