Myelodysplastic syndrome patients present more severe respiratory muscle impairment and reduced forced vital capacity : is disordered inflammatory signaling the culprit?

• Author(s): Okubo, Bruno Memória ; Matos, Anacélia Gomes de ; Ribeiro Junior, Howard Lopes ; Borges, Daniela de Paula ; Oliveira, Roberta Taiane Germano de ; Castro, Marilena Facundo de ; Martins, Manoel Ricardo Alves ; Gonçalves, Romélia Pinheiro ; Bruin, Pedro Felipe Carvalhedo ; Pinheiro, Ronald Feitosa ; Magalhães, Silvia Maria Meira
• Date: 2017
• Origin: Oasisbr
• Subject(s): Myelodysplastic syndrome; Respiratory Muscle; Músculos Respiratórios
• Document Type: Journal article
• Language: English

Description

The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory muscle strength and lung function in elderly patients with anemia, compare data between myelodysplastic syndromes and non-clonal anemias and evaluate the influence of serum IL-8 level and NFkB activity on deteriorate pulmonary function in this specific population.