Author(s):
Teixeira, Maria V. S. ; Lima, Jefferson Q. ; Pimenta, Antônia T. A. ; Silva, Francisca R. L. da ; Oliveira, Maria da Conceição F. de ; Pereira, Italo G. ; Costa-Junior, Dilailson C. ; Ribeiro, Paulo R. V. ; Santiago, Gilvandete M .P. ; Lima, Mary Anne S. ; Braz-Filho, Raimundo ; Bezerra, Mirna M. ; Montenegro, Raquel C. ; Rocha, Danilo D. ; Moraes, Maria Elisabete Amaral de ; Medeiros, Aline C. de ; Arriaga, Angela M. C.
Date: 2018
Origin: Oasisbr
Subject(s): Tephrosia; Flavonoides; Flavonoids
Description
The organic extracts from stems, roots and leaves of Tephrosia egregia Sandwith, Fabaceae, provided anew flavone, 5-hydroxy-8-(1 ,2 -epoxy-3 -hydroxy-3 -methylbutyl)-7-methoxyflavone (1), in additionto eleven known compounds: pongaflavone (2), praecansone B (3), 12a-hydroxyrotenone (4), praecan-sone A, 2 ,6 -dimethoxy-4 ,5 -(2 ,2 -dimethyl)-pyranochalcone, pongachalcone, maackiain, -sistosteroland its glucoside, p-cumaric acid and cinnamic acid. The structures of all compounds were establishedon the basis of spectroscopic methods, mainly 1D and 2D NMR and HRESIMS, involving comparison withliterature data. Cytotoxicity of compounds 1–4 was evaluated against AGP-01 (cancerous ascitic fluid),HCT-116 (colon adenocarcinoma), HL-60 (leukemia), PC-3 (prostate carcinoma), SF-295 (glioblastoma)and SKMEL 28 (melanoma) cell lines.
