Author(s): Bandeira, Tereza de Jesus Pinheiro Gomes ; Moreira, Camila Alencar ; Brilhante, Raimunda Sâmia Nogueira ; Castelo-Branco, Débora de Souza Collares Maia ; Araújo Neto, Manoel Paiva de ; Cordeiro, Rossana de Aguiar ; Rodrigues, Terezinha de Jesus Santos ; Rocha, Marcos Fábio Gadelha ; Sidrim, José Júlio Costa
Date: 2014
Origin: Oasisbr
Subject(s): Amoxicilina; Doxiciclina
This study aimed at investigating the in vitro activities of amoxicillin-clavulanate, doxycycline, ceftazidime, imipenem, and trimethoprim- sulfamethoxazole against Burkholderia pseudomallei in planktonic and biofilm forms, through broth microdilution and resazurin-based viability staining, respectively. In planktonic growth, the strains were susceptible to the drugs, while in biofilm growth, significantly higher antimicrobial concentrations were required, especially for ceftazidime and imipenem, surpassing the resistance breakpoints. These results highlight the importance of the routine evaluation of biofilm antimicrobial susceptibility.
