Author(s):
Paradiso, P. ; Colaço, R. ; Mata, J. L. G. ; Krastev, R. ; Saramago, B. ; Serro, A. P.
Date: 2017
Persistent ID: http://hdl.handle.net/10400.26/20044
Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
Project/scholarship:
info:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F71990%2F2010/PT;
info:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F00100%2F2013/PT;
info:eu-repo/grantAgreement/FCT/3599-PPCDT/M-ERA.NET%2F0005%2F2012/PT;
Subject(s): Soft contact lenses; Liposomes; Drug release; Eyelid; Friction
Description
This is the accepted version of the following article: J Biomed Mater Res B Appl Biomater. 2017 Oct;105(7):1799-1807, which has been published in final form at http://dx.doi.org/10.1002/jbm.b.33715. This article may be used for non-commercial purposes in accordance with the Wiley Self-Archiving Policy [http://olabout.wiley.com/WileyCDA/Section/id-820227.html].
In this article, liposome-based coatings aiming to control drug release from therapeutic soft contact lenses (SCLs) materials are analyzed. A PHEMA based hydrogel material loaded with levofloxacin is used as model system for this research. The coatings are formed by polyelectrolyte layers containing liposomes of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and DMPC + cholesterol (DMPC + CHOL). The effect of friction and temperature on the drug release is investigated. The aim of the friction tests is to simulate the blinking of the eyelid in order to verify if the SCLs materials coated with liposomes are able to keep their properties, in particular the drug release ability. It was observed that under the study conditions, friction did not affect significantly the drug release from the liposome coated PHEMA material. In contrast, increasing the temperature of release leads to an increase of the drug diffusion rate through the hydrogel. This phenomenon is recorded both in the control and in the coated samples.
