Author(s): Silva, João Pina da
Date: 2015
Persistent ID: http://hdl.handle.net/10451/27103
Origin: Repositório da Universidade de Lisboa
Subject(s): Benefits; Mestrado Integrado - 2015; Off-label; Oncology; Toxicity; Treatment; Ciências da Saúde
Author(s): Silva, João Pina da
Date: 2015
Persistent ID: http://hdl.handle.net/10451/27103
Origin: Repositório da Universidade de Lisboa
Subject(s): Benefits; Mestrado Integrado - 2015; Off-label; Oncology; Toxicity; Treatment; Ciências da Saúde
Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015
The off-label use of drugs in oncology is widespread and has a big importance in the present. Although off-label is common in other medical areas, it is shown that the complexity of cancer treatments makes it vital in this area. Studies have demonstrated that more than 50% of regimens are not approved for what they are being used. Due to the fact that each anticancer drug may be of use in several types of cancer, it is frequent that some haven't got the label for the indications under which they can be applied. In this work, off-label use is compared with first line treatments, approved by the regulatory agencies, and results are analysed. The problems related with off-label are also discussed, both from the doctor's and the patient's point of view.